这是一个人人都会经历的重要阶段，对生活的困惑，对事业的沮丧，构成了中年危机的一道独特的风景线……内德（列维·施瑞博尔饰）和詹妮（海伦·亨特饰）是一对正处在某种混乱和危机中的中年夫妻，他们共同养育着两个男孩乔纳（埃兹拉·米勒饰）和伊桑（斯盖勒·福尔特冈饰）,——特别是当他们的祖父厄尼（布莱恩·丹内利饰）搬过来与他们一起住的时候，所有的一切也愈发地开始向着无法控制的未知方向发展着。

汤普森夫妇要出去庆祝结婚纪念日，他们平时的保姆来不了，于是他们请了保姆的朋友安娜来照看孩子…

Claire is sure of herself, her work and family, until - like a bad dream - her husband disappears, leaving a trail of puzzling secrets that shatter her certainty. Three weeks after Claire’s husband has mysteriously disappeared, the police have ended their investigation and her son is beginning to grieve. The only person who hasn’t given up is Claire. Soon she discovers his troubling secrets, including an alluring yet manipulative graduate student with whom he had formed a close bond. As she digs deeper, Claire begins to lose her grip on how well she truly knew her husband and questions her own identity in the process. Claire in Motion twists the missing person thriller into an emotional take on uncertainty and loss.